The year is 1954. U.S. Marshal Teddy Daniels and his new ­partner, Chuck Aule, have come to Shutter Island, home of Ashecliffe Hospital for the Criminally Insane, to investigate the disappearance of a patient. Multiple-murderess Rachel Solando is loose somewhere on this barren island, despite having been kept in a locked cell under constant surveillance. As a killer hurricane bears relentlessly down on them, a strange case takes on even darker, more sinister shades—with hints of radical experimentation, horrifying surgeries, and lethal countermoves made in the cause of a covert shadow war. No one is going to escape Shutter Island unscathed, because nothing at Ashecliffe Hospital is remotely what it seems.

US Marshal Teddy Daniels has come to Shutter Island, home of Ashecliffe Hospital for the Criminally Insane, to find an escaped murderer named Rachel Solando. As a killer hurricane bears down on the island, the investigation deepens and the questions mount. How has a barefoot woman escaped from a locked room? Who is leaving them clues in the form of cryptic codes? And what really goes on in Ward C? The closer Teddy gets to the truth, the more elusive it becomes. And the more he begins to believe that he may never leave Shutter Island. Because someone is trying to drive him insane...